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The combination preferable when possible, because through accident or design some the i eople whom aim benefit may fail eat one the above prophylactics, and this danger reduced a minimum if several such prophylactics are used.

Passing the unknown with regard beriberi there are three problems that are the utmost scientific interest.

These may stated as follows.

The relationdiip between dry and wet beriberi. Are these two types the disease caused the deficiency the same vitamine or different vitamines?.

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What the physiological action the vitamines? Do they act as indispensable building stones for certain tissues, or are they concerned in some other manner, for instance, in carbohydrate metabolism?.

What the chemistry the vitamines? The sdution these problems not only great importance a proper understanding beriberi, but will probably throw much lig upon other deficiency diseases and upon our conceptions physidogical problems.

The niaiidnM'p between dry and wet ert. Althon the paralytic symptoma in beriberi may easily explained as a result the degeneratians tlutt occur in the nervous system, no rational explanation the occurrence the anasarca and effusioDs that characterize wet beriberi has been afforded. If the pathological condition known as dry beriberi and that known as wet beriberi are both produced as the result a deficiency one vitamine, what the explanation the well-known feet that in one epidemic most the cases will the dry type, while in another epidemic most the cases will the wet type? I have thought, that a probable explanation novel writing helper admission essay writing service this strange phenomenon afforded the theory that dry beriberi caused the deficiency one vitamine, while wet beriberi caused the deficiency another vitamine. There a certain amount experimental evidence in favor this theory, since has been foimd that a simple alcoholic extract rice polishings contains substances that will produce an immediate cure in cases wet beriberi, while entirely ineffective in the treatment dry beriberi.

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However if the rice polishings are treated in a different manner, the vita cme the paralytic Bymptoms dry writing custom beriberi. These facte at least indicate the possibility that rice isbings contain two distinct though probably chemically related Titamines. Unfortunately concliudye evidence as the truth or falsity tills theory has not yet been obtained because a suitable experimental animal has been lacking. Fowls and pigeons are ideal experimental animals for the production dry beribm but appear suffer rarely, if at all, from wet beriberi, and rpical wet beriberi can not produced with any degree regularity in any the common laboratory animals. Howerer, within the past year Rommel and Vedder, have found that pigs fed polished rice suffer from wet beriberi pay for paper in a considerable percentage cases. Further woric now in progress, and hoped that, having found a suitable experimental animal, an explanation the rdation between dry and wet beriberi. Whai the phytioloffieal action vikxmines, I have been strongly the opinion that the vitamine dry beriberi a building stone which essential for the metabolism the nervous tissues.

This nion based upon the following facts. If the supply this vitamine cut down feeding exclusively polidied rice, changes in the structure the nerve fibres fowls may demonstrated afteronly days such a diet. The evidence beginning degeneration at such an eariy date i pears indicate that a certain amount this vitamine constantiy necessary in Older business school essay writing service maintain the nervous system in a healthy condition. The nerve cells from the cord fowls suffering from polyneuritis galHnarum I esent changes very similar those demonstrated in the nerve need help with introduction to paper cdls birds that suffer from fatigue as the result long flints. Fowls suffering from polyneuritis may completely cised within a few homa the administration the vitamine obtidned from rice poMshings. This evidence at least strongly suggests that this vitamine a constituent tiiat essmtial the normal metabolinn nervous tissue. 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