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At a certain stage this autodigestion the split products the serum protein exhibit toxic properties.

Biological properties these toxic substances indicate their resemblance the anaphylatoxin and suggest that the anaphylatoxin Fiiedberger, whether occurring in vivo or produced in vitro, a result the autodigestion serum and not the Our findings as cited above showed that there no experimental evidence the existence specific ferments, and that the phenomena parenteral digestion ascribed Vaughan the activity specific argumentative writing homework help ferments can plausibly explained and experimentally demonstrated without assimiing the existence in the body a special specific mechanism outside antibody formation. Having thus answered the first question which set out study will try answer the second one namely, that, assuming the above mechanism parenteral digestion correct why, then, in some cases, the introduction protein into normal animals results in the establishment heightened resistance, whereas in other cases leads heightened vulnerability? As have stated above, the activation normal ferments present in specific sera, through the changes in colloidal dispersion following the union in vivo between the antigen and antibody, may lead digestion antigen as well as that the serum itself.

When the antigen mainly digested the phenomenon interpreted the observer as that protection. When the serum or other autogenous elements are digested, the split products being toxic the animal, the intoxication occurs and the observer interprets symptoms as a sign heightened vulnerability.

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It evident from the above that the actual mechanism parenteral digestion in the body the animal previously injected with the homologous protein, and thus possessing the circulating specific antibody the same in both cases namely, the antigen upon its reintroduction anchored antibody and this union leads the liberation normal proteolytic ferments the serum.

It only at this point that the difference may come in, depending upon which substratum mainly attacked this ferment. There must at this point, therefore, the main problem the situation, What determines the direction the activity the ferments? Is this activity selective and directed exclusively toward sensitized antigen in one case and the serum protein in the other, or the difference in two cases only quantitative and not qualitative? Our experiments point the second as a correct answer. It true some our findings seem show that sensitized antigen more readily digested the ferment in momentu mascendi and thus there ight a degree selective action the part a ferment. But experiments in this direction are very difficult and the amount work actually done not yet sufficient essays on community service for definitely claim such the case. On the other hand, and in the majority experiments, there seems no selective action the part the ferment.

Both the serum itself and the antigen seem equally subject the attack.

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What, then, determines the write my paper for me degree toxicity developed dining this process parenteral digestion? First all, course, the amount the autogenous toxic split products liberated during digestion.

And this seems in direct relation with the amount antigen It well established experimentally that, no matter how small may in certain cases, the dose antigen introduced into a sensitized animal must sufficient produce the anaphylactic shock. If the amount antigen too small the shock does not take place, although the experimental animal may show other, milder symptoms, It thus evident that the amount antigen reintroduced into a sensitized animal a very important factor in determining the degree intoxication. On the other hand experiments have definitely shown that exposure sensitized animals cold or starvation may reduce the toxic effect the injection a lethal dose antigen. These where to buy research papers cheap experiments suggest that not only the actual amount antigen introduced help writing university assignments but also the rapidity with wldch unites witJi the antibody, may influence the rapidity liberation ferments and resulting intoxication. This relation may still better demonstrated the known fact that instead injecting at once a lethal dose antigen into a highly sensitized animal, one would inject the same and even a larger amount very slowly, the acute anaphyl tic shock might averted. Thus the degree toxicity developed during parenteiul digestion in sensitized ftnimfr apparently websites for essay writing determined the amount digestion taking place in a unit time, and this in turn depends the amount antigen injected in a unit time. Such a view the phenomenon would explain, seems, how that parenteral digestion, following reintroduction antigen, may at times seemingly protect the animal, whereas at other times injures its well-being. If the amount antigen reintroduced into a sensitized animal small or introduced very slowly, the amount ferment liberated in unit time very slight, and the amount autogenous split products may small that the animal may show no apparent term paper buy online symptoms intoxication. If, however, the amount antigen sufficient, and if introduced rapidly, the rate activation the ferment great and the animal succumbs intoxication In case natural reinfection with pathogenic microoiganisms the amount antigen which penetrates into the body sensitized animals usually small enough, and even research papers buy if multiplies i need help writing my essay in the body at buy research papers online cheap the beginning, the process slow and the extent autodigestion in a unit time slight that the reaction occurs without the visible injury the host, and this why the observers called the process protective and the animal immune. If, however, the same animal artificially given a large dose the same antigen, a large amount ferment liberated rapidly, causing anaphylaxis, and call the same animal hypersensitive. Howevw, the amount the antigen and the rate its introduction into sensitized animals a arently not the only mechanism controlling the rate parenteral digestion as judged the appearance toxic split products. It observed, for instance, that animals receiving systematic injections toxic foreign protein at short intervals can develop their resistance Hie given toxic substance such a degree that multiple toxic dose toxic antigen may injected, no matter how rapidly, without producing even the slightest symptoms.

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