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Approaching the question the mechanism anaphylaxis scientific paper writing services at this stage its development, the investigator confronted with a fimdamental question Assuming that the anaphylactic shock due the liberation poison in the body sensitized animals through the specific cleavage following the reinjection antigen, what the mechanism this cleavage? In order answer this question one must first determine the nature changes place in the normal physiological processes the animal, following the first custom writing plagiarism experimental parenteral introduction the foreign protein. On the one hand, the hypothesis Ehrlich suggests that such parenteral introduction foreign protein followed the production specific antibodies. On the other Vaughan and his followers, without definitely denying the production antibodies, asstune that parenteral introduction foreign protein followed the output specific ferments.
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In fact Abderhalden states definitely that the parenteral introduction foreign protein followed the production specific ferments parallel with the production specific antibodies, but independent the latter.
If the interpretation the phenomena observed Abderhalden correct, the production specific ferments seems an even more general mechanism than that production antibodies. For antibodies have been thus far demonstrated only, in cases parenteral introduction substances animal or plant protein origin, provided that this protein foreign the species. Specific paraphrasing sources ferments, however, are claimed have been demonstrated not only thesis research proposal upon the parenteral introduction such substances but also upon that proteins homologous, and even autogenous nature, provided these substances were foreign the blood blutfremd. Moreover, the parenteral introduction substances like gelatin, pepton, cane sugar, or casein, claimed the Abderhalden school produce specific ferments, capable attacking said substances, both in vitro and in vivo. Thus the group substances which can play the part antigen in the production antibody included in that the substances capable causing the production specific ferments, but only Such a conception parenteral digestion, first examination, seems very useful as a working hypothesis, for, if possible prove the presence such specific ferments, all findings from the realm immunity can brought into the sphere biochemistry. The just criticism which the chemists had for a long time against the conception immimologists who dealt with antibodies and alexins terms which seem name but not designate the still unknown substances would immediately answered.
It thus that a nimiber men, familiar with phenomena immunity, and anxious find the general physiological principles underlying this very important mechanism, have turned their attention the possibilities offered the methods investigation enunciated Abderhalden. In repeating the work Abderhalden and his collaborators in this laboratory, however, came doubt their conclusions.
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Our experiments have shown that, although under certain conditions experiment the antigen may actually digested the ferments the blood prepared animals, the ferments responsible for such digestion are not specific. In fact, as others have shown before the digestive ferments are present in every fresh serum, and, if set free, can digest any suitably prepared substratum in vitro without any specific predilection.
According the findings a number investigators, the activity ferments normally present in the serum usually inhibited a simultaneous presence antiferments in the serum. The hire freelance writers removal the latter liberates the active ferments and allows digestion take place. Indeed, Bordet, Nathan, Plant, Flatow, and others have demonstrated quite definitely that mere mechanical adsorption any the substances like agar, kaoUn, starch, and the like, may free serum its antiferments and thus liberate the normal ferments. On the other hand, as Schwartz and, more recently, Jobling and Peterson have shown, serum lipins may also inhibit the activity normal ferments the serum, and their removal, as found even change in their physical state may result in activation the normal nonspecific ferments the serum.
It thus that a number authors tried explain the digestion, accredited Abderhalden the activity newly produced specific ferments, assuming that was due the mechanical adsorption antiferments the substratum and subsequent liberation normal nonspecific ferments. Our own experiments, however, convinced that such not the case. We found that although the ferments concerned buy college paper online in the digestion are not specific inasmuch as they can made digest any substratum, the phenomenon as a whole not devoid a certain degree specificity and, therefore, could not reduced mechanical absorption antiferments. Our systematic study this question brought the conclusion that the element specificity lies, not in the ferment itself, but in the mechanism its activation namely, found that the apparent specificity ferment action in vivo, assumed Vaughan and demonstrated in vitro the methods Abderhalden, due the fact that the combination specific serum with its corresponding antigen, in vivo as well as in vitro, followed a radical change in the degree dispersion serum colloids. This physico-chemical change in turn followed the activation a normal, nonspecific ferment the serum. If such a conception correct, then the phenomenon specific parenteral digestion may explained a basis very similar that offered the chemical theory Vaughan but, instead specific ferments, the digestion will ascribed normal nonspecific ferments, present in any help paraphrasing fresh serum complement and set free a specific mechanism combination between the antigen and antibody very similar that recorded the meiostagmin reaction Ascoli. As was mentioned above, the toxic phenomena in anaphylaxis are ascribed the chemical theory the action the split products antigen, attacked the active principle the senun the sensitized animal.
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