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It noticed, however, that a similar animal inoculated with a similar dose antigen, the only difference being that between the time the last serial injection and the test injection sufficient time will elapse, will succumb with anaphylactic shock.

In both cases the amount antigen and the rapidity injection being the same, evident that the difference in time elapsed between the last serial injection and the test injection determines the difference in the effect the respective test injections.

Just what happens in the sensitized animal dxiring this period time, called incubation period, differently explained different authors.

Our own experiments lead believe that the reason for the difference in the response the sensitized animals reinjection in the two cases cited above as follows The union between the antigen and antibody, as have suggested above, reduces the inhibiting power the serum-antitrypsin and thus liberates its normal ferments.

Such can the case only long as the remaining amount antiferment not too great interfere with the action the ferment as liberated. If the amount antiferment too great, may delay or altogether prevent the cheap article writing service digestive action the ferments.

When antigen introduced parenterally into a normal animal once or in serial injections, such antigen digested.

It known that the products such digestion are strongly antitryptic.

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i need help writing an analysis essay It thus that as the digestion progresses there going all the time the formation new antitryptic split products, which are eventually either assimilated the cells in the constructive process the body or are eliminated. Such removal excess antitryptic elements however, not rapid, and as long as the antitryptic split products the antigen from the previous injection remain in circulation the rapid action newly formed ferments prevented and anaphylaxis does not occur. If, however, enough time allowed pass, usually about days, before the test injection given the excess antitryptic products previous parenteral digestion are removed and a rapid action ferments thus made possible.

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Such rapid digestion may cause the shock.

That this view correct also follows from the analysis the phenomenon called vaccination against anaphylaxis. It was good fortune study the phenomenon anaphylaxis in Besredka's laboratory, i need help writing a essay when found that, if the treated animal should given a second injection antigen before the expiration full incubation time after the first injection, such an animal does not respond with anaphylactic shock the test injection at the time expected days after the first injection, but later. Moreover, the larger the dose antigen injected, the longer the state hypersensitiveness delayed and the period resistance prolonged.

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This phenomena suggested Besredka the possibility using in order avoid the undesirable reaction in anaphylactic animals. Namely, succeeded in preventing anaphylactic shock in animals having passed the incubation period after their first or after their last serial injection merely injecting a sublethal dose the antigen some short time previous the following test injection several lethal doses antigen. This experiment was laid in the basis the method which used every day now for the prevention serum sickness in children receiving more than one injection diphtheria antitoxin. The mechanism such vaccination against anaphylaxis was found that retardation ferment action the circulating split products remaining from the digestion, following the vaccinating injection antigen, and not exhaustion antibody, as assumed others. Such a state seeming resistance anaphylaxis, as called, the state antianaphylaxls, was produced many other procedures than vaccinating injection antigen. Thus was found that administration anesthetics, sedatives, top ghostwriters and many other toxic substances may prevent the subsequent development anaphylaxis. The mechanism such action the substances just referred was never adequately explained. Having convinced ourselves that in the case vaccination against anaphylaxis the mechanism involved was that increase antitrypsin, tried see if the same could also buy a philosophy paper true in the other cases. Actual measurements have shown this the case. We found that, without exception, the administration substances known have the effect preventing the anaphylactic shock followed a more or less marked increase in antitryptic properties the blood.

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