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These earlier theories, however, did not find confirmation in subsequent investigations. At present the consensus opinion among workers in this field scientific endeavor seems point the assumption that, in the measiue in which the development new properties business school essay writing service in the blood experimental animals responsible for the establishment either heightened or diminished specific resistance, the same set substances supposed confer these outwardly contradictory changes in tolerance animals, reinjection foreign proteins.

There remains, however, an open question as the nature these new properties the blood serum, as well as the mode their action. Still less definite information as the reason why these changes, brought about in experimental animals the parenteral introduction foreign protein, should produce a seemingly opposite effect the natural tolerance animals these substances. The changes in tolerance a given protein, following a single or a multiple systematic introduction the same protein Into experimental animals, have been studied and variously interpreted different investigators.

But for very slight minor differences all the theories suggested can brought back two fundamental theoretical conceptions. One, assuming after Ehrlich, that the foreign protein, introduced parenterally into the experimental animal, anchored such cells the body as happen possess chemically active radicals receptors, with specific chemical ftfl for corresponding chemically active radicals the protein introduced antigen.

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The union the respective radicals in virtue their specific chemical afiinity followed the neutralization the chemical avidity the cell concerned, and the subsequent restoration and overproduction the cell professional college application essay writers the radicals saturated antigen.

This phenomenon studied and described Weigert leads finally the condition in which the cell finds itself overburdened with the radicals in question, and at a certain time during the process such a cell who will write my essay casts off into the circulation the excess these chemically active radicals.

Such substances, appearing in the circulation, as a response the cells the introduction a foreign body, are known under the name antibody.

The antibodies, according this view, retain, while free in the circulation, their power combine with and anchor the homologous protein when such reintroduced later. Whereas the anchoring antigen the specific BsceptoiB the ll followed incorporation such antigen into the body the cell virtue the general digestive mechanisms the cell, the detached receptors, circulating in the blood stream, combine with such specific antigen without digesting but merely changing such antigen in a manner in which becomes more easily attackable leucocytes, as well as the complement, which supposed the active principle directly responsible iot cytolytic as well as albuminolytic According the other fundamental theory, represented best the work Vaughan and his collaborators, the parenteral introduction foreign protein stimulates the cheap term papers online production specific ferments within the body experimental animals.

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Such ferments, circulating in the blood stream, attack and digest directly the homologous protein when reintroduced later.

Although the above conceptions differ very substantially from each other the question the intimate nature mechanisms governing the physiological processes, following the introduction foreign protein into the animal body, both theories, in fact, indicate that such foreign protein undeigoes parenteral assimilation, or digestion in the broader sense the term, and thus eventually eliminated from the circulation. It this element ridding the body the foreign material which responsible for the view the whole process as i need help with writing a paper a protective mechanism, especially because practically all the protein substances, when introduced parenteraUy, are apt exhibit different degrees toxicity, if the amount injected sufficiently great. Whichever the two views upon the mechanisms parenteral need help with essay paper digestion correct, the careful observers, beginning with Jenner and Magendi, have noticed repeatedly that, parallel with the apparent development specific protective mechanisms, the parenteral introduction protein foreign the body may give rise also other mechanisms detrimental the well-being the animal. According the views the school following in the footsteps Ehrlich, the reason for such paradoxic action parenteral introduction protein the fact that during the extracellular specific lysis formed as well as unformed protein antigen in reinjected animals, this antigen broken down through the action complement, and the poisons preexisting in the unaltered antigen are thus liberated. Such a view was considered especially plausible siuce Vaughan had shown that any protein can broken chemical means, as yield a very powerful poison. Friedberger, who deserves especial credit for most the work in this direction, has shown that such poisons could produced in the test tube imitating the specific lysis, supposedly taking place in the body. In his earlier experiments Friedberger obtained from normal guinea-pig serum, which had been allowed stand for some time with the washed specific precipitate formed rabbit serum immunized against sheep serum with the serum the latter, very strong poisons, which killed the guinea pigs instantly with symptoms acute shock. He named the poisonous substance anaphylatoxin, and assimied that arose from the digestion the specific precipitate the ferments normal guinea-pig senun complement. According the views Vaughan and his followers, toxic phenomena in anaphylaxia are due the split products direct digestion antigen, the specific ferments present in the blood and tissues sensitized animals. More recently there has appeared a great number publications concerning the question the mechanism the specific parenteral digestion. Abderhalden and his collaborators M are primarily responsible for this work, have taken the theory specific ferments, and using specially devised methods seemingly demonstrated in vitr the presence such ferments in the blood prepared animals. These findings, if correct, seem offer a valuable link in the chain reasoning the earlier supporters the theory specific ferments.

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