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The conclusion obvious that all are stages the same organism, Bartonella haeUltformis, The schizogonic cycle Bartonella in warm blood can easily followed in these stages.

We have only assume the existence, in the salivary glands Phlebotomus vermearum, the sporozoites, a stage as yet undetected but certainly existing analogy with the life cycle similar pathogenic organisms. All these findings indicate conclusively that Bartonella a protozoan. Several which are easily explained, have proved stumblingblocks, however, in the inteq retation the asexual development the organism.

It has been repeatedly demonstrated that blood containing mature gametes Bartonella fails originate any ssrmptoms upon injection into healthy animals that the gametes disappear from the erythrocytes upon the advent the eruption that impossible grow these gametes in ordinary culture media that eruption-tisBue inoculations produce localized proliferation lesions in new tissues without gametes Bartonella i pearing in the erjrthrocytes bid writing services and that such lesions may produced successively in series animals such inoculations. These and related facts are what induced Drs. Strong announce the fever and eruptive stages verruga as two distinct pathologic entities. But their finding in Oroya fever cases the schizonts and merozoites Bartonella, already shown characteristic the eruption tissues, appears bind inseparably their Oroya fever and verruga peruviana.

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The explanation the several facts above It evident that the greater numbers the Bartonella sporozoites introduced the Phlebotomus within the skin susceptible subjects immediately embed themselves in the cytoplasm the vascular endothelial cells at points inoculation. Once embedded, they devdop into schizonts, which upon maturing break into merozoites, the latter elongating within the unruptured host-cell walls and penetrating such rthrocytes as come into direct contact with the infected cell, whereupon they become immature gametes. The fully formed rods and ovals in the erythrocytes are respectively the mature male and female gametes, which can conjugate only in the Phlebotomus, or at least in cold blood.

Hence their injection into a healthy warmblooded animal fails originate any ssrmptoms the disease. There appears no duplication or repetition any the stages, thesis writing far as the forms already found afford any index, except that the mature male gametes may increase binary transverse division. But there some reason believe that the merozoites before elongation may under certain conditions devdop into schizonts. The endothelial cells the capillaries the subcutaneous tissues are evidently the chief seat the above-described schizogonic or asexual cycle Bartonella, and here where the erythrocytes mostly become infected. The fever stage follows the extensive breaking the schizonts in the endothelial cells the capillaries, and coincides with the extensive penetration the erythrocytes the merozoites. The toxin resulting from the multiplication Bartonella has been liberated in quantity into the blood, causing the rise temperature, the anemia following through hemolysis.

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The eruption, which particularly characterized a great proliferation vascular endothelial cells, the direct result the extensive asexual multiplication Bartonella in the subcutaneous tissues. The prolif ation vascular endothelial paper writing service college cells, incited the toxin resulting from the metabolism Bartonella, not oidy imprisons this toxin, thus arresting the hemolysis, but also prevents the erythrocytes from coming into direct contact with cells containing merozoites, thus cutting short the infection the erythrocytes.

As the natiural result the fever and anemia both subside, and the gametes Bartonella are no longer found in the blood. Erythrocytes can evidently become infected only during their slow passage through the capillaries and while in actual contact essay writing homework help through positive chemotzopism with a Irving infected endothelial cell in situ in the capillary wall. Evidently the infected cell positively chemotropic for normal freshly-oxygenated erjrthrocytes, attracting and holding them in contact with itself until transfer a certain number merozoites has been e£fected, which decreases the oxygen tension in their substance, thereby transforming their tropic qualities, the sufficiently infected erythrocytes being set free through negative chemotropism. Hence eruption-tissue inoculations produce no gametes in the erythrocytes the subject inoculated, for the merozoites contained in such material, enveloped as they are masses proliferation, are obviously unable come in contact, under proper conditions, with the erythrocytes in the new tissues. Eruption-tissue inociilations are, in a sense, mere transplantations or essay help chat grafts, as proved the fact that the resultant proliferation strictly localized. They are comparable not only in behavior, but also a considerable degree in character, the do my papers grafts carcinoma and other tumors which have been effected within recent years.