Although not improbable that the presence a local tumor may stimulate a reaction which unfavorable for the development tumor emboli, experimental evidence this lacking, and the peculiarities the individual tumor with respect its common app essay help ability disseminate its cells should taken into consideration.
Tumors which metastasized in the individuals in which they ori inated have a greater tendency than others Certain points with respect conditions governing the growth tissues are readily determined in human beings. The following observations were made with respect the persistence transplants the abnormal tissue in myelogenous leukemia academic editing service an Hodgkln's disease during the course certain procedures that were undertaken the members the staff the Himtington Hospital with the view testing the efficacacy autologous vaccinations which was at that time trial in the treatment Myelogencms leukemia.
These observations show that the abnormal cells in these two diseases not find the conditions furnished the subcutaneous tissues favorable for their development.
Diagnostic tests and curative sera.
A considerable portion the work immunity spontaneous tumors has been done in connection with human cases and falls natmrally into two divisions first, the reactions which might serve as diagnostic or prognostic tests, and second, measures which have been carried out with the view efifecting a cure sume general form treatment. Among the proposed diagnostic methods may mentioned Freund's reaction, the meiostagmin reaction, the hemolysis test, Abderhalden's test, the cobra venom test, and complement fixation. As poeaible ciirative agents, trypain, sera from resistant human cases, living tumor used as an autologous vaccine, tumor extracts and cell ferments, dried animal tumon, and the transfused blood normal individuals have been employed.
Since the various tests each require separate consideration no discussion them will undertaken. It notable, however, that the present time these have in general been found either unreliable or impractical.
Although the transplanted tumors rats and mice are especially favorable for experimentation, there has been more or lees discrepancy in the results obtained different investigators. Explanation for this found both in differences in the biological character the various tumon employed as well as in differences in the character the animals with which these are tested. Russell has employed in his investigations a great number tumors, the immunizing qualities which has determined testing them upon mice the same breed with adequate ccmtrols with respect age and weight.
The author has attacked the problem from the diametrically opposite side and has tested the reaction different varieties mice a single tumor.
Thus while in the expenments one a stock tame mice was taken as thb Indifferent or constant and the tumor as the variable factor, in the expenments the others a single tumor served as write my thesis paper the constant and different varieties mice and their hybrids as the variables. General featuret. Immunity transplanted tumor has as its basis the reaction the organism a foreign cell. It has been shown that animals treated with normal cells may manifest an increased resistance implanted tumor and also that animals treated with tumor tissue may subsequently show pronounced immunity the same tumor or other tumon. The condition resistance implantaticm various types tumon the previous injection a single tumor has been termed panimmunity Ehrlich. Differences in the immunizing qualities various tumon has been definitely established Russell, who has foimd that in general the poorly growing tumon serve as the more efficient antigens. Loeb, Haaland, and the author have each shown that tumon may readily reimplanted in the individuals in which they arise autoplastic grafting. When a tumor transferred other individuals the same race, a variable nimiber failures growth usually occur, and greater difficidty encountered in the successfid implantation tumor tissue in other races and varieties homololastic grafting. Practically invariable failure follows the implantation tumor in other species heteroplastic grafting.
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